Antiangiogenic activity of endostatin inhibits c6 glioma growth
نویسندگان
چکیده
منابع مشابه
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models
The combination of Endostatin (ES) and Herpes Simplex Virus thymidine kinase (HSV-TK) gene therapy is known to have antitumor activity in bladder cancer. The potential effect of ES and TK therapy in glioma has not yet been investigated. In this study, pTK-internal ribosome entry site (IRES), pIRES-ES, and pTK-IRES-ES plasmids were constructed; pIRES empty vector served as the negative control. ...
متن کاملFluvastatin inhibits growth and alters the malignant phenotype of the C6 glioma cell line.
BACKGROUND Fluvastatin is a member of the family of HMG-CoA reductase inhibitors (statins) extensively used in medical practice. Increasing evidence suggests that fluvastatin may be implicated in suppression of cancer growth and development. The aim of the present study was to investigate the anti-cancer potential of fluvastatin in C6 rat malignant glioma cells. METHODS First, the effects of ...
متن کاملAntiangiogenic Factor Endostatin Studied by Molecular Dynamics
Tumor growth depends on its capacity to induce formation of new blood vessels [1]. Endostatin, a 20-kDa C-terminal fragment of collagen XVIII, is a potent antiangiogenic agent, fully inhibiting tumor growth in mouse models [2]. Since 2000, endostatin has been tested in patients as an experimental therapeutic agent. Results of clinical trials show that tumor size is not reduced under endostatin ...
متن کاملAntiangiogenic Therapy for Glioma
Currently, antiangiogenic agents are routinely used for the treatment of patients with glioma. However, despite advances in pharmacological and surgical therapy, glioma remains an incurable disease. Indeed, the formation of an abnormal tumor vasculature and the invasion of glioma cells along neuronal tracts are proposed to comprise the major factors that are attributed to the therapeutic resist...
متن کاملComparison of the antiangiogenic activity of modified RGDRGD-endostatin to endostatin delivered by gene transfer in vivo rabbit neovascularization model
PURPOSE Endostatin plays an important role in inhibiting corneal neovascularization (CNV). The aim of this study was to evaluate the antiangiogenic activities of lipid-mediated subconjunctival injection of the modified RGDRGD (arginine- glycin- aspartic- arginine- glycin- aspartic- endostatin gene in a rabbit model of neovascularization in vivo. METHODS A modified human endostatin gene contai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2002
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.10115